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Several factors can compromise a stool specimen, including contamination with urine or water, which can dilute or alter the sample. Additionally, the presence of certain medications, such as antibiotics or barium from imaging studies, can interfere with test results. Delays in processing the sample or improper storage conditions, like exposure to heat or light, can also lead to degradation of the specimen. Finally, using the wrong type of container or not following collection guidelines can further affect the integrity of the stool sample.

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