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Calcification in the vasculature is primarily caused by the accumulation of calcium phosphate crystals in the arterial walls, often due to processes associated with aging, inflammation, and vascular injury. Factors such as elevated levels of cholesterol, Diabetes, and chronic kidney disease can contribute to this condition by promoting inflammation and altering normal calcium metabolism. Additionally, the presence of certain cell types, such as vascular smooth muscle cells, can lead to the transformation of these cells into osteoblast-like cells, further facilitating calcification. Overall, vascular calcification is a complex interplay of metabolic, inflammatory, and mechanical factors.

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2mo ago

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