a slightly low serum globulin probably has no significance, say 1.9 (where the low end of normal range is 2.2 or 2.3) unless associated with some other disease, such as kidney nephrosis or liver disease.
low immunity
Low levels of globulin, specifically hypoalbuminemia, can be caused by a variety of factors including malnutrition, liver disease, kidney disease, gastrointestinal disorders, and certain genetic conditions. Globulins are proteins produced by the liver and immune system, so any disruption in these systems can lead to decreased levels. Further diagnostic testing may be needed to determine the underlying cause of low globulin levels.
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Low globulin levels can indicate conditions such as liver or kidney disease, malnutrition, or autoimmune disorders. Globulins are proteins that help support the immune system and regulate blood viscosity, so low levels may compromise immune function and overall health. It is important to consult a healthcare provider for proper diagnosis and management if low globulin levels are detected.
Low serum globulin levels can be associated with myelodysplastic syndrome (MDS), a group of disorders caused by poorly formed or dysfunctional blood cells. In MDS, the bone marrow fails to produce healthy blood cells, leading to cytopenias and potential immune dysregulation, which may result in altered protein levels, including globulins. Additionally, low globulin levels may indicate chronic disease or inflammation, which can further complicate the clinical picture in patients with MDS. Therefore, monitoring serum globulin can provide insights into the disease's progression and the patient's overall health status.
Because of haemodilution,albumin is low and fibrinogen and globulin are high which improve stacking of red blood cell.
I also would like to know
exposed toHBV s it treated with injections of hyper immune globulin
According to the chart that came with the blood information about my current blood test, albumin is 4.1 and ALT (SGOT is 49). What does this mean? Janet
Alpha globulin
Low albumin levels could indicate malnutrition or liver disease, while high levels of alpha 1 and alpha 2 globulins could suggest acute inflammation or infection. Further evaluation, such as liver function tests and inflammatory markers, would be needed to determine the underlying cause.
Low globulin can be due to immune deficiency associated with decreased antibody production. This would also account for lower total protein (because globulin is a protein), however it would not account for the low calcium level. Calcium is bound to protein in the blood, so low protein can be associated with a spruriously low calcium (i.e. a calcium number that is low without actual calcium deficiency). This may be the case if the albumin (another protein) is low, and there is a formula to correct calcium for low albumin, where: Corrected Calcium = (0.8 * (Normal Albumin - Pt's Albumin)) + Serum Ca Alternatively, an ionized calcium level can be checked and will be normal if the serum calcium was only low due to low albumin. Without knowing the clinical context (which would be very helpful), the most likely single explanation for low globulin, low total protein, and low serum calcium is protein nutritional deficiency. In this case, the body is overall protein deficient and so it is not uncommon to find a decrease in all protein levels (especially if severe). In this case, the low serum calcium is due to low albumin, as above. This can be further explored by checking a pre-albumin level (typically low if protein deficiency due to poor diet). You should talk to the physician who orderd the tests for a better answer, as only he or she knows why the tests were ordered and can interpret them in the appropriate clinical context.