What causes hemosiderin deposition?

Answer 1

Hemosiderin deposition occurs when there is an accumulation of excess iron in the body, typically resulting from conditions such as hemochromatosis, repeated blood transfusions, or excessive dietary iron intake. It is a complex composed of aggregates of denatured ferritin, which is the protein responsible for iron storage. The body’s inability to effectively utilize or excrete this excess iron leads to the formation of hemosiderin, often seen in tissues like the liver, spleen, and bone marrow. This deposition can eventually cause tissue damage and organ dysfunction if not managed properly.