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Many, many things. Dehydration, for one, can be very injurious to the kidneys. Infections, especially chronic and recurring pyelonephritis, can damage the kidneys. Many congenital disorders are problematic. Kidney cancer, and cancers which metstastasize to the kidneys is another category. Medications and drugs, either certain types, or excess amounts are often very damaging. And many, many more.

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