What causes low red blood cellcount when iron level are high?

Answer 1

A low red blood cell count with high iron levels can be caused by several factors, including anemia of chronic disease, where inflammation interferes with red blood cell production despite adequate iron. Additionally, conditions like thalassemia or certain bone marrow disorders can lead to ineffective erythropoiesis, resulting in low red blood cell counts even when iron stores are sufficient or elevated. It's also possible for liver disease to disrupt iron metabolism and erythropoiesis, leading to similar outcomes.