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The most common cause of nerve endings to the shoulder results from a proximal humerus fracture. Running circumferential to the proximal end of the humerus is the axillary nerve. Injury to the humerus such as fractures or subluxation can directly injure the axillary nerve resulting in possible sensation loss or muscle weakness around the deltoid, teres minor and triceps muscle.

Other causes of injury:

- Injections (for e.g. cortisone) and vaccinations: if given too high in the anterior (front part) aspect of the deltoid, may result in the rupture of the axillary nerve

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