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Do T cells express MHC II?
No, T cells do not express MHC II. MHC II molecules are primarily found on antigen-presenting cells, such as dendritic cells, macrophages, and B cells, and are involved in presenting antigens to T cells for immune responses. T cells, on the other hand, express MHC I molecules, which present antigens to other immune cells.
Difference between MHC class1 and MHC class2 molecules?
MHC proteins express antigens on a cell surface for T cells to identify whether the antigens presented are self or foreign. There are two classes MHC I and MHC II. They differ in which cells they require to activate depending on the pathogen present.
When an antigen binds to a Class 1 MHC molecule it stimulates what cell?
Class I MHC molecules present antigens to cytotoxic T-cells (which are CD3+CD8+).
Class II MHC molecules are found only on which of the following?
Presented by APCs as MHC-exogenous peptide complex
Do neurons have mhc class 1 receptors?
Yes, neurons can express MHC class I receptors on their surface under certain conditions. This expression is important for immune surveillance and can contribute to neurological disorders when dysregulated.
Where are major histocompatibility complex-you MHC-you molecules located?
Each individual has a unique MHC profile Clinically important MHC are HLA(human leukocyte antigens) -A, -B -DR -expression of a particular combination of MHC genes Class I - are located on all nucleated cells Class II - are located on macrophages, dendritic cells, B cells.
Do T cells have major histocompatibility complex (MHC) molecules?
Yes, T cells have major histocompatibility complex (MHC) molecules.
B-lymphocytes express both MHC-1 and MHC-2?
Yes they do. MHC 1 are expressed by all nucleated calls (except neurones) and platelets. MHC 11 are expressed by B-cells, macrophages and dendtitic cells. Therefore, some cells express both types.
Does thymic selection destroy MHC molecules?
Thymic selection does not destroy major histocompatibility complex (MHC) molecules. Instead, it helps in the development of T cells by allowing them to recognize self-MHC molecules and self-antigens to ensure self-tolerance and proper immune function.
What is the difference between T cell receptors and MHC molecules?
T cell receptors bind to MHC class 1 molecules. MHC class 1 molecules bind to peptides (self or foreign) and present it to the cell's membrane. The job of a T cell is to decide what is presented on the MHC class 1 cell whether to leave it alone or to activate to destroy it because it is non-self.
In Grave's autoimmune disease of the thyroid?
thyroid cells produce class-2 MHC molecules that stimulate autoantibodies that bind to the TSH receptor
When an antigen is bound to a class II MHC protein it can activate what cell?
When an antigen is bound to a class II MHC protein, it can activate helper T cells. Helper T cells play a critical role in initiating and coordinating immune responses by releasing various signaling molecules and activating other immune cells.
