There are two classes of MHC. MHC I are expressed in all cells except red blood cells (because they lack nuclei). MHC I andMHC II are expressed in professional antigen presenting cells (APC's) that include :macrophages, dendritic cells and B cells.
No, T cells do not express MHC II. MHC II molecules are primarily found on antigen-presenting cells, such as dendritic cells, macrophages, and B cells, and are involved in presenting antigens to T cells for immune responses. T cells, on the other hand, express MHC I molecules, which present antigens to other immune cells.
MHC proteins express antigens on a cell surface for T cells to identify whether the antigens presented are self or foreign. There are two classes MHC I and MHC II. They differ in which cells they require to activate depending on the pathogen present.
Class I MHC molecules present antigens to cytotoxic T-cells (which are CD3+CD8+).
Presented by APCs as MHC-exogenous peptide complex
Yes, neurons can express MHC class I receptors on their surface under certain conditions. This expression is important for immune surveillance and can contribute to neurological disorders when dysregulated.
Each individual has a unique MHC profile Clinically important MHC are HLA(human leukocyte antigens) -A, -B -DR -expression of a particular combination of MHC genes Class I - are located on all nucleated cells Class II - are located on macrophages, dendritic cells, B cells.
Yes, T cells have major histocompatibility complex (MHC) molecules.
Yes they do. MHC 1 are expressed by all nucleated calls (except neurones) and platelets. MHC 11 are expressed by B-cells, macrophages and dendtitic cells. Therefore, some cells express both types.
Thymic selection does not destroy major histocompatibility complex (MHC) molecules. Instead, it helps in the development of T cells by allowing them to recognize self-MHC molecules and self-antigens to ensure self-tolerance and proper immune function.
T cell receptors bind to MHC class 1 molecules. MHC class 1 molecules bind to peptides (self or foreign) and present it to the cell's membrane. The job of a T cell is to decide what is presented on the MHC class 1 cell whether to leave it alone or to activate to destroy it because it is non-self.
thyroid cells produce class-2 MHC molecules that stimulate autoantibodies that bind to the TSH receptor
When an antigen is bound to a class II MHC protein, it can activate helper T cells. Helper T cells play a critical role in initiating and coordinating immune responses by releasing various signaling molecules and activating other immune cells.