During depolarization Na channels are open
During repolarization K channels are open
The stage that immediately follows depolarization in an action potential is repolarization. During this stage, potassium channels open and potassium ions move out of the cell, leading to a restoration of the cell's negative charge.
During an action potential, the major events include depolarization (sodium channels open, sodium ions enter the cell), repolarization (potassium channels open, potassium ions leave the cell), and hyperpolarization (potassium channels close slowly leading to an overshoot of the resting membrane potential). Sodium influx causes depolarization, while potassium efflux causes repolarization and hyperpolarization.
During repolarization, potassium channels open and potassium ions exit the cell, causing the inside of the cell to become more negative. This process restores the cell's resting membrane potential. It follows the depolarization phase, where sodium channels open and sodium enters the cell, causing the inside of the cell to become more positive.
Voltage-gated sodium channels open during the depolarization phase of an action potential, when the membrane potential becomes more positive.
It has to do with what types of channels are open during this phase. In the repolarization phase the number of potassium channels are increased and the number of sodium channels are decreased. This allows for action potentials to not occur. Otherwise, the action potentials would add up and produce tetany.
Almost as soon as the depolarization wave begins, voltage-gated potassium channels open in response to the increase in membrane potential, allowing potassium ions to move out of the cell. This efflux of potassium ions causes repolarization of the cell membrane by restoring the negative resting membrane potential.
Voltage-gated sodium channels open when the membrane potential reaches a certain threshold during the depolarization phase of neuronal signaling.
Action potentials cannot be generated during the absolute refractory period, as not enough ion channels are able to respond to the stimulus, no matter how large it is. Using Na+ fast channels as an example, during depolarization the "gate" of the channel is opened, allowing for Na+ influx into the cell. However, during the repolarization phase, a second "gate" marks the closure of the cell, preventing any further movement of ions into the cell. However, this also means that the channel is unable to open again until the second gate is removed, and the first gate returns back into place.
In depolarization, voltage-gated sodium channels open first, allowing sodium ions into the cell, resulting in action potential generation. This is followed by voltage-gated potassium channels opening to repolarize the cell.
The entry of sodium ions into the neuron and their diffusion to adjacent areas of the membrane causes those portions of the membrane to become depolarized and results in the opening of voltage-gated sodium channels farther down the axon, which release potassium ions to the outside, returning the charge to its previous state
Fast Calcium
Repolarization is the phase in which the membrane potential returns to its resting state after depolarization. This is achieved by the outflow of potassium ions from the cell, restoring the negative charge within the cell relative to the outside. Repolarization is crucial for resetting the cell's electrical potential and preparing it for the next action potential.