Not only does the hemoglobin prefer CO, it holds on to the CO much more tightly, forming a complex called carboxyhemoglobin (COHb).
carbon monoxide (CO)
A complex salt is the salt of one or more complex ions, the complex part can be cationic or anionic or both such as Ca3[Co(Cl)6]2 the complex part behaves as an anion [Co(NH3)6]Cl3 the complex part behaves as a cation [Co(NH3)6][Co(Cl)6] the both of the anionic and cationic parts of the are formed by complex ions
CO (carbon monoxide). It binds to the same sites on hemoglobin that oxygen would, except with a much greater affinity than oxygen does. Think of hemoglobin as a bus transporting oxygen from the lungs to the peripheral tissues, and think of CO as the guy who takes oxygen's seat so that he can't ride the bus. CO is also the chemical that kills people in house fires from smoke inhalation.
The harmful effects of carbon monoxide (CO) does not manifest itself in the lungs. Rather CO acts as a gas similar to oxygen, it diffuses through the lungs tissue as normal and binds to hemoglobin, which is normally used to transport oxygen around the body by binding to it and carrying it around. However, this is where CO becomes harmful. CO enters the bloodstream and binds to hemoglobin with a far greater affinity that oxygen, in essence inactivating the hemoglobin molecule. Therefore hemoglobin is unable to properly transport oxygen since it is already bound up by CO and hypoxia sets in quickly. There is no way to "cure" CO poisoning in the way to chemically unbind CO from hemoglobin, this is why individuals with CO poisoning must be removed from the CO environment and given 100% oxygen to breath, to allow the slow process of CO dissociation from hemoglobin to occur.
CO Carbon monoxide is combined with hemoglobin and carboxyhemoglobin is formed; this compound block the diffusion of oxygen in blood.
The chemical formula for the complex ion formed when cobalt(III) chloride hexahydrate is dissolved in water is Co(H2O)63.
CO (carbon monoxide). It binds to the same sites on hemoglobin that oxygen would, except with a much greater affinity than oxygen does. Think of hemoglobin as a bus transporting oxygen from the lungs to the peripheral tissues, and think of CO as the guy who takes oxygen's seat so that he can't ride the bus. CO is also the chemical that kills people in house fires from smoke inhalation.
The affinity of hemoglobin for CO is roughly 20,000 times greater than that of oxygen in vitro. In vivo, the affinity of hemoglobin for CO is roughly 200-225 greater than that of oxygen. ------------------------------------------------------------------------------------------------- O2 has stronger bond than CO. Therefore, the oxygen in CO loves the iron in the hemoglobin as iron ends with two electrons which complete the 6 electrons in the oxygen. In vivo, the affinity of hemglobin for CO is about 153 from 141x153/141. by amin elsersawi
This is not the main reason:The molecular mass of CO is 28 a.m.u while that of O2 is 32 a.m.u therefore the rate of diffusion of CO is higher than O2 and it enter fast into respiratory track and lungs and causes the deficiency of oxygen.Added:(The more important reason is):CO is about 200 times more reactive to 'ferro'-hemoglobin than O2, so it can hardly be replaced by the available excess of oxygen in air, thus preventing the life-essential O2-transfer to parts of the body like brains and hart & lung muscles.(Cf. 'Related links' down this answering page)
CO
Carbon monoxide binds to hemoglobin in red blood cells with a higher affinity than oxygen, forming carboxyhemoglobin. This reduces the amount of hemoglobin available to bind oxygen, leading to decreased oxygen delivery to tissues.
The charge of the co ligand in a coordination complex is typically neutral.