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He noticed that milkmaids who had suffered from cowpox didn't suffer smallpox, this lead him to believe that the cowpox prevented smallpox. He tested this on James Phipps, he infected the boy with pus from a milkmaids cowpox boil, he caught cowpox. Jenner then infected the boy with smallbox, but Phipps didn't catch it. This was the first inoculation. Jenner was given grants to find other inoculation's, but failed as he was unsure why immunity was given. It wasn't till Pasteur's (anthrax and rabies vaccines) time that other vaccines were discovered.

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