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Archaea share some characteristics with known pathogens that may reflect the potential to cause disease. Such characteristics include ample access to a host (i.e., opportunity) and capabilities for long-term colonization and coexistence with endogenous flora in a host. The detection of anaerobic archaea in the human colonic, vaginal, and oral microbial flora demonstrates their ability to colonize the human host. Details regarding their survival in such human niches, including human immune system evasion and competition with normal human flora, however, are largely unavailable. No definitive virulence genes or factors have been described in archaea to date. Nevertheless, archaea may have the means, and they certainly have the opportunity, to cause disease.

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