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What does Autoimmune hemolytic anemia do?
It occurs when the body produces antibodies that coat red blood cells
Can clozapine cause hemolytic anemia?
Hemolytic anemia indicates the early destruction of red blood cells. This can occur as inherited or acquired hemolytic anemia. Certain medicines can cause acquired hemolytic anemia, please check with the doctor.
What is the treatment of dapsone induced hemolytic anemia?
anemia
What is the prognosis for hemolytic anemia?
In about 15% of cases, the baby is severely affected and dies before birth. Babies who survive pregnancy may develop kernicterus, which can lead to deafness, speech problems, cerebral palsy, or mental retardation.
What is spherocytes?
Spherocytes are abnormally shaped red blood cells that appear more round and compact than their normal biconcave disc shape. They can result from conditions like autoimmune hemolytic anemia, hereditary spherocytosis, or certain infections. Spherocytes have increased fragility and decreased flexibility, which may lead to their premature destruction and contribute to anemia.
How does someone catch hemolytic anemia?
Someone can catch hemolytic anemia from their parents. When a child is born and if the parents possess this condition, it can be passed on to the child.
What does slight polychromasia mean?
hemolytic anemia
What are spherocytes?
Spherocytes are abnormally round red blood cells that lack the central pallor seen in normal red blood cells. They are often associated with certain medical conditions such as autoimmune hemolytic anemia. Spherocytes are more fragile than normal red blood cells and may be removed from circulation more rapidly, leading to hemolytic anemia.
How is hemolytic anemia diagnosed?
physicians will examine the blood for the number of young red blood cells, since the number of young cells is increased in hemolytic anemia.
What causes hemoglobinuria?
most commonly hemolytic anemia
MCHC indication when it is below and above normal?
When the mean corpuscular hemoglobin concentration (MCHC) is below normal, it may indicate conditions such as iron deficiency anemia or thalassemia. When the MCHC is above normal, it can be seen in conditions like hereditary spherocytosis or autoimmune hemolytic anemia.
Idiopathic autoimmune hemolytic anemia?
DefinitionIdiopathic autoimmune hemolytic anemia is a drop in the number of red blood cells due to increased destruction by the body's defense (immune) system.Alternative NamesAutoimmune hemolytic anemia; Anemia - idiopathic autoimmune hemolyticCauses, incidence, and risk factorsIdiopathic autoimmune hemolytic anemia is an acquired disease that occurs when antibodies form against a person's own red blood cells. In the idiopathic form of this disease, the cause is unknown.Idiopathic autoimmune hemolytic anemia accounts for one-half of all immune hemolytic anemias.There are other types of immune hemolytic anemias in which the cause may result from an underlying disease or medication. The disease may start quickly and be very serious.Risk factors are not known.SymptomsDark urineFatiguePale color (pallor)Rapid heartbeatShortness of breathYellow skin color (jaundice)Signs and testsAn examination may reveal an enlarged spleen.Tests include:Direct Coombs' testHemoglobin in the urineIndirect Coombs' testRed blood cell count and serum hemoglobinReticulocyte countSerum bilirubinlevelsSerum haptoglobinTreatmentThe first therapy tried is usually a steroid medication, such as prednisone. If steroid medications do not improve the condition, removal of the spleen (splenectomy) may be considered.Therapy to suppress the immune system is usually given if the person does not respond to steroids and splenectomy. Medications such as azathioprine (Imuran), cyclophosphamide (Cytoxan), and rituximab (Rituxan) have been used.Blood transfusions are given with caution, because of the potential that blood may not be compatible and may cause further hemolysis.Expectations (prognosis)Adults may have long-term disease that keeps returning. In children the anemia is usually short-lived.ComplicationsInfection (as a complication of treatment)Severe anemiaCalling your health care providerCall your health care provider if you notice symptoms of anemia.PreventionThere is no known prevention for idiopathic autoimmune hemolytic anemia, because the cause is unknown.ReferencesSchwartz RS. Autoimmune and intravascular hemolytic anemias. In: Goldman L, Ausiello D. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 164.Powers A, Silberstein LE. Autoimmune hemolytic anemia. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 47.
