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There are many drugs that weaken the immune system, but people would likely be most familiar with corticosteroids (eg: Glucocorticoids). Corticosteroids are produced naturally by our bodies, but are also commonly given in higher doses to treat many different human ailments, such as Asthma (an asthma puffer is often administering corticosteroids). The immunosuppressant nature of corticosteroids is exactly why they are effective drugs. For example, the symptoms of Arthritis, an inflamatory disease (inflammation is caused by the immune system), are alleviated by corticosteroids by reducing the inflammation. Someone who is about to undergo an organ transplant will also often have their immune system suppressed with corticosteroids so that the transplanted organ will be less likely to be rejected.

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