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Black urine is often caused by the presence of melanin or other pigments, which can result from certain metabolic disorders. One enzyme associated with this condition is homogentisate oxidase, which is deficient in individuals with alkaptonuria, leading to the accumulation of homogentisic acid. This acid can oxidize and create a dark pigmentation in urine. Other conditions, such as certain infections or hemolysis, may also contribute to dark urine but involve different biochemical pathways.

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4mo ago

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