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Substances that facilitate or mimic the activity of a neurotransmitter system are known as agonists. These can include drugs, hormones, or natural compounds that bind to neurotransmitter receptors and activate them, producing effects similar to those of the natural neurotransmitter. For example, morphine acts as an agonist for the endorphin system by binding to opioid receptors, leading to pain relief. Additionally, some substances can enhance neurotransmitter release or inhibit their reuptake, further amplifying their effects in the synaptic cleft.

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