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Familial hypercholesterolemia (FH) affects both genders, but studies suggest that men may be more severely impacted than women, particularly at younger ages. This difference is partly due to the protective effects of estrogen in premenopausal women, which can mitigate cholesterol levels. However, the overall prevalence of FH is similar in both sexes, and the condition can lead to significant cardiovascular risk for both men and women if left untreated.

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