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The Rh factor is associated with issues in pregnancies. Rh- (Rh- negative) people do not automatically carry anti- Rh antibodies but the immune system will manufacture them if exposed to Rh+ blood. If the Rh- negative mother has not been exposed to Rh+ blood the first pregnancy will progress without complications. However upon delivering her first child the severing of the placenta from the uterus will expose the Rh- negative mother to the Rh+ blood stimulating the production of Rh+ antibodies. If the Rh- woman becomes pregnant with another Rh+ child her antibodies will traverse the placenta and obliterate the infants erythrocytes (RBCs). The baby will develop a condition known as erythroblastosis fetalis which may result in death if untreated prior to birth.

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