Well, you have Down syndrome at that point.
If the membrane did not indent and pinch off during cell division, the two resulting daughter cells would not separate properly. This could lead to abnormal cell division, potentially causing developmental issues, cell death, or the formation of a multinucleated cell.
If the membrane did not properly indent and pinch off during cell division (cytokinesis), the two daughter cells would not fully separate. This would result in a cell with multiple nuclei, which can disrupt cellular function and potentially lead to genetic instability and cell death.
Secretory vesicles pinch off from the Golgi apparatus during the process of exocytosis. These vesicles contain proteins or other molecules destined to be secreted from the cell. Once they pinch off, they move towards the cell membrane to release their contents outside the cell.
Vesicles pinch off of the endoplasmic reticulum (ER), Golgi apparatus, and plasma membrane. These vesicles transport molecules such as proteins and lipids to various locations within the cell or for secretion outside the cell.
Pinch is temporary Cut is permanent
A part of the Golgi complex can pinch off and form a transport vesicle, responsible for carrying proteins and other molecules to their specific destinations within the cell. These transport vesicles bud off from the Golgi apparatus and then fuse with other organelles or the cell membrane to release their contents.
The process you are referring to is called vesicle budding. This occurs when a cell membrane invaginates, forming a vesicle that eventually pinches off to transport cellular material within or out of the cell. This process is essential for cell communication, nutrient uptake, and intracellular trafficking.
At pinch off voltage, the channel is blocked at its maximum. (depletion region blocks almost entire channel, so no charge exchange). Therefore, no drain is flown through the channel.
When a cell needs to take in a particle larger than the membrane channels can passage, it will invaginate the cell membrane around the particle(s) and pinch off part of the membrane containing the particles inside the cell membrane. This is called phagocytosis (when the particles are primarily solid) or pinocytosis (when the particles are primarily liquid).
You can pinch off a part of a loaf of bread, yes. So I would use "off" with the word pinch; however, the phrase in the question might be considered a 'colloquialism,' or local slang, as it is.
Pinocytosis
During cytoplasmic division in animal cells, the cell membrane forms a contractile ring composed of actin and myosin filaments at the equator of the cell. This contractile ring constricts, causing the cell membrane to invaginate and eventually pinch off, resulting in two daughter cells.