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The most common disease associated with the pancreas is Diabetes. This is caused the a total failure of the organ. The total failure is caused by the pancreas is from it being overused. You might know insulin as the thing you take when you have diabetes. Insulin (and glucagon) is secreted in the pancreas. Both of these hormones control your blood sugar level. If it's too high, insulin is released to put the sugar into the surrounding blood vessel cells, and vice versa for glucagon. If you use your pancreas too much (too much sugary foods), then your pancreas is overworked and fails. Then you have to take synthetic insulin to stop the buildup of blood sugar.

Another common condition of the pancreas is pancreatitis (pancreatic inflammation). The most common causes of pancreatitis are gallstones and alcohol consumption.

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