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The active compounds in magic mushrooms (and their metabolites, as psilocybin is metabolized into psilocin, which is also present in the mushrooms) bind to a specific serotonin receptor in the brain, the 5-HT2A receptor. Activation of this receptor leads to the psychedelic effects through poorly understood mechanisms. Contrary to fairly widespread belief, these compounds have not been shown to be neurotoxic or cause damage to the brain.

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