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Long bone growth is primarily controlled by a combination of growth hormone, thyroid hormones, and sex hormones. Growth hormone stimulates bone and cartilage growth, while thyroid hormones regulate overall metabolism which affects bone growth. Sex hormones, such as estrogen and testosterone, play a role in the final stages of bone growth during puberty.
Growth hormone (GH) generally promotes growth and development, particularly affecting the proliferative activity of the growth plate, or epiphyseal plate, in long bones. Increased levels of growth hormone can stimulate the proliferation of chondrocytes, which are responsible for cartilage growth in this area. Therefore, growth hormone is unlikely to cause decreased proliferation at the epiphyseal plate; rather, it typically enhances it, leading to increased linear bone growth. However, excessive GH can lead to conditions like acromegaly, which may affect bone growth patterns.
Corticosteroids can affect growth, especially in children, by inhibiting bone growth and reducing the production of growth hormone. Long-term use of corticosteroids can lead to a decrease in height potential.
Growth Hormone (GH)
Groth in long bones indicates a total lack of hormones.
The growth in bone length of a long bone occurs at the epiphyseal plate, also known as the growth plate. This area is found at the ends of long bones and is responsible for new bone formation during childhood and adolescence, ultimately determining the final length of the bone.
Long bone growth in length occurs at the growth plate, also known as the epiphyseal plate. This is a cartilaginous area at the ends of long bones where new bone tissue is formed, leading to longitudinal bone growth.
The growth plate in a juvenile long bone is a layer of cartilage located near the end of the bone. It allows for bone growth and lengthening during childhood and adolescence. Once a person reaches skeletal maturity, the growth plate closes and is replaced by solid bone.
The growth plate of a long bone is located at the end of the bone, near the joint. It is also known as the epiphyseal plate and is responsible for longitudinal growth during childhood and adolescence.
Metaphysis
metaphysis
Interstitial bone growth in long bones occurs in the epiphyseal plate, or growth plate, located at the ends of long bones. Here, cartilage cells (chondrocytes) proliferate, differentiate, hypertrophy, and are replaced by bone tissue, leading to longitudinal bone growth. This process is crucial for growth and development in children and adolescents.