As I understand it, and I am not a doctor, it is severe scarring from endometriosis that leads to a hole in the uterus. At least this is how it was explained to me when I was diagnosed with it.
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Not quite.
There is NO hole in your uterus.
In Allen-Masters, you have broken the tissue (think of it like skin) that stabilizes your uterus and holds it in one place in your pelvis. Without that tissue holding it in place, your lower uterus (and your cervix and vagina below the uterus) can wiggle around as you move while the rest of the uterus is fixed. This stretching and jolting of the cervix hurts!
See this drawing to get an idea of what your uterus looks like.
http://en.wikipedia.org/wiki/File:Gray1161.png
See your uterus -- that big ball in the center that's sitting on the vagina (which looks like a tube)? Now see the "Broad ligament" on either side that looks like its taping the uterus in place? Well imagine a great big hole in that bottom part of that ligament. The uterus is no longer taped down and it moves.
Holes in the ligament usually come from surgical trauma or old wounds. You can easily break the ligament from delivery or, very rarely, from induced abortion (especially if incompetent/unskilled person filled the vagina with too much gauze after the procedure). A very similar set of symptoms can come from endometriosis.
So to even consider Allen-masters as a diagnosis, you need (1) an overly mobile cervix, (2) A uterus that has lost its support and is pointing the wrong direction, and it helps to have (3) a history of trauma to the pelvis -- by which I mean childbirth etc. Some people would say that the damage caused by endometriosis is close enough to lump it in as trauma to the pelvis.
Symptoms are:
1. Long-lasting pelvic pain
2. Menstrual changes of many kinds
3. Pain with sex
**Note that not EVERYONE with these symptoms has Allen-masters. These are VERY VERY COMMON symptoms in many diseases. This disease is rare.
You can try to treat it surgically. Its a difficult fix.
Down syndrome is a genetic defect and is the result of an extra chromosome at the time of conception. The use of Procardia (or any other drug) does not cause Down syndrome.
A defect on maternal chromosome 15 will cause the sundrome. Since the paternal copy, which is most likely normal is silenced, it makes no difference. Uniparental disomy will also result in the syndrome.
Endometriosis does not cause vaginal odor on its own. However, if there is a bacterial infection present then vaginal odor can result.
It means that if the product is or becomes defective as a result of the workmanship in the production or as a result of a defect in the material, then the manufacturer will replace or repair the goods.
The Allen-Masters syndrome, also known as the Allen-Masters defect, refers to a condition characterized by a combination of uterine and vaginal anomalies due to abnormal development of the Müllerian ducts during embryogenesis. This can result in various reproductive abnormalities, including uterine agenesis or hypoplasia, and may be associated with other congenital malformations. The syndrome can lead to infertility, menstrual irregularities, and complications during pregnancy. Diagnosis often involves imaging studies, and treatment may include surgical intervention or assisted reproductive technologies.
Klinefelter syndrome can result from errors in cell division of sperm or egg cells. With this syndrome, each of the cells of the person affected will have an extra X chromosome.
AIDS (Acquired Immune Deficiency Syndrome)
A Planar Defect is a defect that occurs in crystalline structure of a material either naturally or due to the influence of some outside source, and can result in weakness or poor structural integrity of the material.
Disorders, such as Down's Syndrome, are caused by nondisjunction.
Cushing's Syndrome
enlargment of bloob vessle in the lung result from septal defect
According to the research I've done, Prader-Willi Syndrome is rarely a result of translocation, but it is a possibility. Translocation in this syndrome results in an inactivation of genes on the paternal chromosome 15.