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Serum bicarbonate determination is clinically significant as it helps assess the acid-base balance in the body, which is crucial for diagnosing and managing conditions like metabolic acidosis or alkalosis. Abnormal bicarbonate levels can indicate respiratory or metabolic disorders, kidney function issues, or the body’s response to various diseases. Monitoring bicarbonate levels can guide treatment decisions, such as bicarbonate therapy in acidosis or adjustments in ventilation for respiratory conditions. Overall, it serves as a vital marker in evaluating a patient's overall metabolic status.

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