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In general, the term for a decrease in brain function, along with personality changes and memory loss is called dementia. There are at least 3 diseases that cause dementia. The most popularized one is Alzheimer's Disease. People with it might suffer depression in their 30's and then gradually forget things as they become older, and then they reach a point where they may come across as mean or vindictive when that is not like them.

Parkinson's Disease may have somewhat similar symptoms. They may shake a bit and start to forget things. They also may have some psychological changes.

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