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A defect that causes hemoglobin to become sharp is known as sickle cell disease, which results from a mutation in the HBB gene that encodes the beta-globin subunit of hemoglobin. This mutation leads to the production of hemoglobin S (HbS), which polymerizes under low oxygen conditions, causing red blood cells to assume a rigid, crescent or "sickle" shape. These sickled cells can obstruct blood flow and lead to various complications, including pain crises and organ damage.

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3w ago

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