A chemical that is added to the blood sample in the platelet aggregation test to stimulate the clumping process.
Platelet Count
The platelet aggregation test uses a machine called an aggregometer to measure the cloudiness (turbidity) of blood plasma
aids in the evaluation of bleeding disorders by measuring the rate and degree to which platelets form a clump (aggregate) after the addition of a chemical that stimulates clumping (aggregation).
There are many medications that can affect the results of the platelet aggregation test. The patient should discontinue as many as possible beforehand.
aspirin decrease platelet aggregation
What is the Platelet Count Test?
An aminochromone is an amino derivative of a chromone, some of which block human platelet aggregation.
Carbon monoxide inhibit blood platelet aggregation.
Aspirin works by blocking an enzyme called cyclooxygenase, which is needed for the production of certain chemicals that promote platelet aggregation. By inhibiting this enzyme, aspirin helps prevent platelets from sticking together and forming blood clots.
Risks for this test are minimal in normal individuals. Patients with bleeding disorders, however, may have prolonged bleeding from the puncture wound or the formation of a bruise (hematoma) under the skin where the blood was withdrawn.
drugs that can decrease platelet aggregation include aspirin, some antibiotics, beta blockers, dextran (Macrodex), alcohol, heparin (Lipo-Hepin), nonsteroidal anti-inflammatory drugs (NSAIDs), tricyclic antidepressants, and warfarin
Prostacyclin (PGI2) opposes the action of thromboxane A2. They are both derived from arachidonic acid and have opposite effects on platelet aggregation and blood clot formation. Prostacyclin acts as a vasodilator and inhibits platelet aggregation, counteracting the pro-thrombotic effects of thromboxane A2.