Calcipenia refers to a deficiency of calcium in the body, which can lead to various health issues, particularly related to bone health, muscle function, and nerve signaling. It is often associated with conditions such as osteoporosis, osteopenia, and hypoparathyroidism. Symptoms may include muscle cramps, spasms, and numbness or tingling in the extremities. Addressing calcipenia typically involves dietary changes, supplementation, and treating any underlying causes.