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The World Health Organization classifies oral precancerous/potentially malignant disorders into 2 general groups, as follows:

  • A precancerous lesion is "a morphologically altered tissue in which oral cancer is more likely to occur than its apparently normal counterpart." These precancerous lesions include leukoplakia, erythroplakia, and the palatal lesions of reverse smokers.
  • A precancerous condition is "a generalized state associated with significantly increased risk of cancer." The precancerous conditions include submucous fibrosis, lichen planus, epidermolysis bullosa, and discoid lupus erythematous.
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