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Early senescent small-vessel ischemic changes refer to the initial alterations in small blood vessels that occur due to aging and chronic ischemia, which is a condition characterized by reduced blood flow. These changes can include thickening of the vessel walls, loss of endothelial function, and reduced perfusion to tissues, often leading to cognitive decline and increased risk of vascular diseases. These ischemic changes are typically observed in the context of neurodegenerative conditions and can be a precursor to more severe vascular-related damage. Detection and management of these changes are crucial for preventing further complications.

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