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Intracorpuscular defects refer to abnormalities or dysfunctions within red blood cells themselves, often resulting in conditions like hemolytic anemia. These defects can arise from genetic mutations affecting hemoglobin synthesis, membrane structure, or metabolic pathways within the cells. Common examples include sickle cell disease and thalassemia, where the structural integrity or function of hemoglobin is compromised. These conditions lead to reduced red blood cell lifespan and various clinical symptoms associated with anemia.

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