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The LDL (low-density lipoprotein) receptor is responsible for regulating cholesterol levels in the bloodstream by mediating the uptake of LDL particles into cells. By binding to LDL, the receptor facilitates the internalization of cholesterol and other lipids, thereby reducing the amount of circulating LDL cholesterol. This process is crucial for maintaining cellular function and overall lipid homeostasis, and dysfunction of LDL receptors can lead to conditions such as hypercholesterolemia and increased risk of cardiovascular diseases.
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The process by which cholesterol is transported into the cell by binding of LDL to its receptor and the internalization of the receptor-LDL complex is?
facilitated transport
What is the importance of Receptor-mediated Endocytosis in the genetic disorder Familial Hyper-Cholesterolemia?
In mammalian cells, the LDL (low density lipoprotein) receptor transports cholesterol into the cell via receptor-mediated endocytosis. The cholesterol is then used by the cell for various metabolic functions and the receptor is recycled to the plasma membrane.In patients suffering from Familial Hypercholesterolemia, the genes encoding the LDL receptor are mutated, as a result of which cholesterol is unable to bind to the LDL receptor. This leads to accumulation of cholesterol in the circulation, hence causing disease. Patients suffering from this disease are treated using drugs called Statins, which inhibit an important enzyme involved in cholesterol biosynthesis.
What is an autosomal dominant disorder that results in a defective or deficient LDL receptor known as?
An autosomal dominant disorder that results in a defective or deficient LDL receptor is known as familial hypercholesterolemia. (FH). Most patient with FH do not live beyond 30 without intervention.
Which lipoprotein contains the highest percentage of cholesterol?
HDL has the highest percentage of proteins. LDL has the highest percentage of cholesterol plus cholesteryl esters. LRP is the abbreviation for LDL receptor related protein.
What receptor is responsible for adjusting the light and brightness in your eye?
Photoreceptor
What is the endosomes function?
Endosomes provide an environment for material to be sorted before it reaches the degradative lysosomeAnswers.com. For example, LDLis taken into the cell by binding the LDL_receptorat the cell surface. On reaching early endosomes, the LDL dissociates from the receptor, and the receptor can be recycled to the cell surface. The LDL remains in the endosome and is delivered to lysosomes for processing. LDL dissociates because of the slightly acidified environment of the early endosome, generated by a membrane proton pump V-ATPase. The Mannose_6-phosphate_receptorcarries Ligand_(biochemistry)from the Golgi destined for the lysosome by a similar mechanism.
What does the gene ST2 responsible for?
The gene ST2 is responsible for the suppression of tumorigenicity. This means that this gene is responsible to suppressing tumors, or cells that may cause tumors.
which of the following are responsible for recognizing a change to the system?
receptor cells - apex
What is sensorys receptor for smell?
The sensory receptor for smell is called the olfactory receptor. These receptors are located in the olfactory epithelium in the upper part of the nasal cavity and are responsible for detecting and transmitting odors to the brain for interpretation.
What is the effect of a decrease in the ability of LDL receptors to bind to LDLs?
A decrease in the ability of LDL receptors to bind to LDLs leads to an accumulation of low-density lipoprotein (LDL) particles in the bloodstream. This can result in higher levels of cholesterol in the blood, increasing the risk of atherosclerosis and cardiovascular diseases. Additionally, impaired uptake of LDLs by cells can disrupt lipid homeostasis and contribute to metabolic disorders. Overall, reduced LDL receptor function is associated with adverse health outcomes related to cholesterol metabolism.
What lipoprotein is responsible for transporting cholesterol back to the liver form the periphery?
High-density lipoprotein (HDL)
What is the Function of Endosomes?
Endosomes provide an environment for material to be sorted before it reaches the degradative lysosomeAnswers.com. For example, LDLis taken into the cell by binding the LDL_receptorat the cell surface. On reaching early endosomes, the LDL dissociates from the receptor, and the receptor can be recycled to the cell surface. The LDL remains in the endosome and is delivered to lysosomes for processing. LDL dissociates because of the slightly acidified environment of the early endosome, generated by a membrane proton pump V-ATPase. The Mannose_6-phosphate_receptorcarries Ligand_(biochemistry)from the Golgi destined for the lysosome by a similar mechanism.
