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Trisomy of chromosome 12 is one of the most frequent cytogenetic abnormalities in karyotype chronic lymphocytic leukemia (CLL). A high incidence deviation in B-cell CLL is the deletion of chromosome 13 (13q14) is detected using modern diagnostic methods such as Southern blot hybridization, and fluorescence in situ hybridization. It occurs in 51% of the CLL patients and up to 70% of mantle cell lymphoma. The deletion of a locus on 13q14.3 affect telomere to the RB1 gene (retinoblastoma) gene and the marker D13S25 that bears with respect to a candidate tumor suppressor gene.

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