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Multiple foci of increased radiotracer uptake in the skull, as seen in imaging studies like a PET scan, may indicate various conditions such as metastatic disease, primary bone tumors, or infections like osteomyelitis. This pattern suggests areas of increased metabolic activity, often associated with malignancy or inflammation. Differential diagnoses should be considered, and further evaluation, including clinical correlation and additional imaging, may be necessary to determine the underlying cause.

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