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Tetrodotoxin is a neurotoxin. It acts to neuronal depolarization and prevent subsequent action potentials via binding to the voltage gated sodium channels on the cell membrane.
In a healthy neuron, these voltage gated sodium channels are critical for generation of an action potential in response to graded depolarization (I.e. EPSP). As the neuron is depolarized, these channels open and allow for the influx of sodium ions into the cell, which in turn further depolarized the neuron in a positive feedback loop.
Tetrodotoxin (TTX) is the toxin found in blowfish (fugu).
Another harmful substance for the nervous system is manganese which causes manganism, resembling some aspects of Parkinson's disease.
Off the top of my head: 6-HO-dopamine, MPTP, ibotenic acid. Wikipedia these neurotoxins for their respective mechanisms of action
Source: degrees in neuroscience and neuropharmacology
What else can I help you with?
What can go wrong with the nervous system?
You could get brain damage if something affects your nervous system.
What is the difference the somatic nervous system and the autonomic nervous system?
Autonomic is the automatic nervous system eg pain response (something you cannot not control) while the somatic nervous system is the thing we can control.
How do they keep the nervous system healthy?
Complex vitamin B. Every B vitamin has something to do with the nervous system.
What system makes you react when you touch something sharp?
Your nervous system.
What body system connects tissues and organs to the brain?
The brain belongs to the Central Nervous System(CNS) of the human Nervous System.
What are the 2 subgroups of the nervous system?
vines and something else
Would you have a stroke if you had something wrong with your nervous system?
Strokes are more commonly from something wrong in the circulatory system causing there to be something wrong in your nervous system, specifically, that part of your brain either temporarily or permanently stops receiving oxygen and dies.
Which system would send signals to inform your body to do something to maintain homeostasis?
The Nervous System
What organ system does the brain belong too?
The nervous system The central nervous system
Does the central nervous system consist of the somatic nervous system?
No. Nervous System is comprised of the Central Nervous System (CNS) and the Peripheral Nervous System (PNS) The PNS is comprised of the Somatic Nervous System and the Autonomic Nervous System The Autonomic Nervous System is comprised of the Sympathetic Nervous System, the Parasympathetic Nervous System and the Enteric Nervous System
What comprises the nervous system?
The Sympathetic Nervous System and the Parasympathetic Nervous System
The portion of the nervous system away from the central nervous system?
The peripheral nervous system is the portion of the nervous system away from the central nervous system. It consists of nerves that connect the central nervous system to the rest of the body, including sensory and motor neurons. The peripheral nervous system is responsible for transmitting information to and from the central nervous system.
