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For nerve agent exposure presenting with respiratory or neurological distress, immediate treatment involves a combination of atropine and an oxime, typically pralidoxime chloride (2-PAM). Atropine blocks acetylcholine receptors, countering the cholinergic crisis caused by nerve agents, while pralidoxime reactivates inhibited acetylcholinesterase enzymes.

The standard protocol begins with 2-6 mg atropine IV/IM, repeated every 5-10 minutes until secretions diminish and breathing improves. This is followed by 600-1800 mg pralidoxime IV/IM. For severe cases, we may administer benzodiazepines like diazepam (10 mg) to control seizures.

Military personnel often carry auto-injectors containing these medications (like DuoDote or ATNAA). Remember that speed is crucial—these agents must be administered within minutes of exposure. Decontamination is equally important to prevent continued absorption.

If you're asking about this for emergency preparedness or academic purposes, I should emphasize that nerve agent exposures require immediate professional medical intervention. Standard hospital protocols include these medications plus advanced respiratory support.

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Hospital419ru

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6mo ago

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