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Backbone therapy typically refers to a foundational treatment approach used in various medical contexts, particularly in oncology and Infectious Diseases. In HIV treatment, for example, it often denotes a standard regimen consisting of two nucleoside reverse transcriptase inhibitors (NRTIs) combined with a third agent, such as a non-nucleoside reverse transcriptase inhibitor (NNRTI) or a protease inhibitor (PI). This combination aims to effectively suppress the virus and prevent resistance. In oncology, backbone therapy may refer to a primary chemotherapy regimen upon which additional treatments can be added.

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1w ago

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