What is the cause of Peyronie's disease?

Answer 1

The cause of Peyronie's disease remains unknown after almost 400 years of study since it was first discussed in the medical literature. It is speculated that there are multiple potential causes for Peyronie's disease, with often more than one cause affecting a man who eventually displays the telltale internal fibrous scar formation, pain and peniledistortion that are essential to diagnose Peyronie's disease.

There are a few causation categories that are held to be significant in Peyronie's disease:

• Genetic predisposition
• Trauma
• Drug or chemical injury
• Diabetes
• Liver damage
• Cigarette smoking

Of this list, the first two factors are most commonly associated in the majority of Peyronie's disease.

Answer 2

The symptom is bending of an erect penis, sometimes with pain. It often interferes with sexual intercourse. Erectile failure associated with the angulation often precedes it.