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Distinguishing feature of the duodenum are the Brunner's glands, whereas the Peyer's patches make the ileum easily identificable. The common bile duct and the pancreatic duct enter the duodenum, whereas the ileum does not receive duct from other organs. Outermost layer of the duodenum is comprised of adventitia as it is located retroperitoneally, while the outermost layer of the ileum is represented by serosa(mesothelial cell are evident). The ileum has also more goblet cells than the duodenum. Duodenum represents major site of iron absorption, while the ileum-B12 absorption.

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