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Technically, the brain tells you when you are "full". The stomach is elastic and can stretch to massive sizes before it actually bursts. Your brain should signal you to stop eating well before this happens.

There is a condition that effects 1 in 32 million people that prevents this signal from being issued by the brain. These people are in a constant state of hunger even after eating massive amounts of food and must be monitored at all times to prevent them from eating themselves to death.

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17y ago

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