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Histamine is a chemical mediator. These are released by mammalian cells and effect their cells in their immediate vicinity. Histamines are released from white blood cells in the airways, they are released in response to injury or an allergen. They cause small arteries and arterioles to dilate and the permeability of capillaries to increase. They produce an inflammatory response where swelling, itching and redness occurs.
Histamines are what causes allergic reactions in people. They can cause hives, itchy skin, runny or stuffy nose and watery eyes.

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