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Most of the conducting portion is lined with ciliated pseudostratified columnar epithelium known as respiratory epithelium . This epithelium has at least five cell types, all of which touch the thick basement membrane:

§ Ciliated columnar cells ) are the most abundant, each with about 300 cilia on its apical surface

MEDICAL APPLICATION

Immotile cilia syndrome, a disorder that causes infertility in men and chronic respiratory tract infections in both sexes, is caused by immobility of cilia and flagella induced, in some cases, by deficiency of dynein, a protein normally present in the cilia. Dynein participates in the ciliary movement

§ Goblet cells are also abundant in some areas of the respiratory epithelium , filled in their apical portions with granules of mucin glycoproteins.

§ Brush cells are a much more sparsely scattered and less easily found, columnar cell type, which has a small apical surface bearing a tuft of many short, blunt microvilli . Brush cells express some signal transduction components like those of gustatory cells and have afferent nerve endings on their basal surfaces and are considered to be chemosensory receptors.

§ Small granule cells are also difficult to distinguish in routine preparations, but possess numerous dense core granules 100-300 nm in diameter. Like brush cells, they represent about 3% of the total cells and are part of the diffuse neuroendocrine system

§ Basal cells, small rounded cells on the basement membrane and not extending to the luminal surface, are stem cells that give rise to the other cell types.

Respiratory potion lined by simple squamous epithelium.There are two types of neumocytes lined by alveoli type1 and type2 . Type 2 cells secrete surfactant.

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