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The Löwenstein-Jensen culture method is regarded as the gold standard for diagnosing TB, Dr. Moore and colleagues noted in the Oct. 12 issue of the New England Journal of Medicine. It is highly accurate but takes up to six weeks to deliver a result.
In a large scale, operational test in Peru, the microscopic-observation drug-susceptibility (MODS) assay out-performed two reference methods, automated mycobacterial culture and culture on Löwenstein-Jensen medium, according to David Moore, M.D., of Imperial College London.
By contrast, the median time in this study for the new method to deliver a result was seven days, the researchers said, and its accuracy was significantly better than the Löwenstein-Jensen culture method.
An additional benefit is that it can immediately detect drug resistance, Dr. Moore and colleagues said, allowing more effective treatment from the beginning.
"New diagnostic tools are urgently needed to detect TB and multidrug-resistant TB," said Robert Gilman, M.D., of Johns Hopkins University Bloomberg School of Public Health, a co-author.
"MODS is just such a tool," Dr. Gilman said. "It will change the practice of TB testing in developing countries."
The MODS assay is based on three principles, the researchers said: that Mycobacterium tuberculosis grows faster in a liquid medium than in solid, that the characteristic cord formation can be seen early through a microscope, and that adding TB drugs to part of the culture allows direct drug-susceptibility testing at the same time.
Preliminary work on the assay showed it was able to distinguish TB patients from healthy controls. For this study, the researchers looked at three cohorts populations in Peru. These were unselected patients with suspected tuberculosis seen at 10 government clinics in Lima, patients at high-risk of TB or multidrug-resistant TB seen at five separate clinics, and unselected patients admitted to two Lima hospitals for HIV infection.
In this study, technicians using the assay placed liquid culture from sputum samples in 12 wells of a 24-well tissue-culture plate. Four of the wells contained only the culture and the remaining eight wells contained one of four TB drugs in one of two concentrations.
What else can I help you with?
Can you use icd code v74.1 as a primary diagnosis to rule out pulmonary tuberculosis?
no
Can Ultrasound find stones?
It has become the "gold standard" for diagnosis of stones in the gallbladder, but is less accurate in diagnosing stones in the bile ducts
Who was the first to adopt the gold standard?
The gold standard was first adopted in Britain in 1821Read more: gold-standard
What has the author Neil W Schluger written?
Neil W. Schluger is an author who has written books on pulmonary and respiratory medicine, with a focus on tuberculosis. He has also contributed to numerous scientific articles and research publications in the field of respiratory diseases.
What has the author B Bandelier written?
B. Bandelier has written: 'A clinical system of tuberculosis, describing all forms of the disease' -- subject(s): Tuberculosis 'Tuberculin in diagnosis and treatment' -- subject(s): Tuberculin
What is the abbreviation for diagnosis?
The standard abbreviation for "diagnosis" (at least in North American hospitals) is Dx.
Can a ulcer be seen on CT scan?
The answer is "sometimes". The gold standard for diagnosis of peptic ulcers is endoscopy, specifically esophagogastroduodenoscopy (which views the esophagus, stomach, and duodenal portion of the small intestine).
What is biapical scarring from?
From what I have been told and what I have read, there are many causes for Biapical Scarring, such as Tuberculosis or pneumonia. In and of itself, it is not really specific to any one diagnosis, but only a Pulmonologist can give you a definitive diagnosis.
What does the G stand for in penicillin G?
penicillin G stands for the phrase gold standard, as in gold standard penicillin.
What is the common abbreviation for diagnosis?
The standard abbreviation for "diagnosis" (at least in North American hospitals) is Dx.
What has the author James Edward Pollock written?
James Edward Pollock has written: 'The elements of prognosis in consumption' -- subject(s): Epidemiology, Therapy, Diagnosis, Tuberculosis, Prevention & control, Obstructive Lung Diseases, Pulmonary Tuberculosis
Who opposed gold standard?
the democrats opposed the gold standard. the republicans supported it.
