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Blood flow is most noticeably different in that it is driven by a central pump: the heart. The blood goes from the heart --> arteries --> arterioles (small arteries) --> capillaries --> venules (small veins) --> veins --> Heart --> Lungs --> Heart --> Arteries (and so on).

Lymph flow on the other hand is driven by passive flow through lymph vessels. The capillaries (see above) are fenestrated, which means they have microscopic holes in them. These holes allow a fluid ultrafiltrate from the blood to pass out into the different tissues. This ultrafiltrate is mixed with waste-products from cells and and other pathogens - and this makes up the basic substances in lymph fluid. The lymph fluid is then gathered by open ended lymphvessels, which transport the lymph towards the center of the body.

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