What is the lesion in Parkinson's disease?

Answer 1

In Parkinson's disease, the primary lesion occurs in the substantia nigra, a part of the brain that produces dopamine. The degeneration of dopaminergic neurons in this region leads to a significant decrease in dopamine levels, which is crucial for regulating movement and coordination. This loss contributes to the characteristic motor symptoms of Parkinson's, such as tremors, rigidity, and bradykinesia. Additionally, the presence of Lewy bodies, abnormal protein aggregates, is often observed in the affected neurons.