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Stage IV melanoma with metastases to the brain generally has a poor prognosis, with median life expectancy typically ranging from a few months to around a year, depending on various factors such as the patient's overall health, response to treatments, and specific characteristics of the tumor. Advances in targeted therapies and immunotherapies have improved outcomes for some patients, but survival rates remain low compared to earlier stages of melanoma. Each case is unique, so individual prognosis may vary significantly.

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