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The biggest difference is that a red blood cell has no nucleus where as a white blood cell does. A red blood cell has no nucleus because it needs all the space inside the cell for the haemoglobin which is stored inside it and is the oxygen attrcting chemical. White blood cells can have either a bean shaped nucleus which would make it a lymphocyte or a double lobed nucleus which would make it a phagocyte. Another difference is that white blood cells are bigger than red blood cells.

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