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It depends on what you mean by "most deadly". Some diseases, like the Bubonic Plague, killed more people than, say, smallpox, but is more easily treatable. The reason the plague killed more people is because it became a pandemic during the middle ages, when medical treatment was unavailable.

Some of the deadliest, however, are:

Bubonic Plague

Smallpox

Anthrax

Tuberculosis

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14y ago

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