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The most common method of bone formation is endochondral ossification, which occurs during the development of long bones. In this process, cartilage models are gradually replaced by bone tissue as the cartilage undergoes calcification and is resorbed by osteoblasts. This method is crucial for the growth and shaping of bones during fetal development and childhood. It contrasts with intramembranous ossification, which primarily forms flat bones like those in the skull.

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