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It is difficult to know the answer to this question for sure, but medical scientists generally consider cluster headaches to be the most painful condition that a human can experience. Cluster headaches are significantly more painful than even the most extreme migraine. They feel sort of like someone is taking a serrated ice pick and is stabbing it violently through your eye and into your brain. This can last for hours. 100% of people who have cluster headaches say that they've never experienced anything more painful in their lives (e.g., including women who have given natural childbirth). Many kill themselves, earning the condition the brutal moniker "suicide headaches."

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